Can anyone help with this?

Recently, MS decided to run its automatic update for several service packs:

--Microsoft .NET Framework 2.0 Service Pack 1 (KB110806)
--Microsoft .NET Framework 3.0 Service Pack 1 (KB929300)
--Security Update for Microsoft .NET Framework, Version 1.1 Service Pack 1 (KB928366)

These updates have failed several times. no amount of re-downloading and running the install works. The result is that certain mission-critical software applications won't open (e.g., QuickBooks). I'm stuck in a cycle of turning off the computer, rebooting, waiting for updates to install...and then no avail. Repairing the software doesn't work.